High-concentration nonavian high-molecular weight hyaluronan injections and time-to-total knee replacement surgery.
J Comp Eff Res
; 9(11): 795-805, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-32643955
ABSTRACT
Aim:
To examine the time-to-total knee replacement (TKR) surgery among patients with high-concentration nonavian high-molecular-weight hyaluronan injection (HMW-HA) compared with those without HA injections. Materials &methods:
Using MarketScan® Commercial claims all patients aged 18-64 who underwent TKR surgery between 2008 and 2017 were identified. Time-to-TKR surgery was compared between patients receiving Orthovisc® (Anika Therapeutics Inc. Bedford MA, USA, referred to as nonavian HMW-HA) injections and patients who did not receive an HA injection.Results:
The median time-to-TKR surgery was 893 days in the nonavian HMW-HA cohort and 399 days in the non-HA cohort (p < 0.001), a difference of 494 days (16.2 months).Conclusion:
This study demonstrates that the time-to-TKR surgery is 16.2 months longer in patients who received treatment with nonavian HMW-HA injections.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adjuvants, Immunologic
/
Arthroplasty, Replacement, Knee
/
Osteoarthritis, Knee
/
Hyaluronic Acid
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Language:
En
Journal:
J Comp Eff Res
Year:
2020
Document type:
Article
Affiliation country:
Estados Unidos