Four-Repeat Tauopathies: Current Management and Future Treatments.
Neurotherapeutics
; 17(4): 1563-1581, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-32676851
ABSTRACT
Four-repeat tauopathies are a neurodegenerative disease characterized by brain parenchymal accumulation of a specific isoform of the protein tau, which gives rise to a wide breadth of clinical syndromes encompassing diverse symptomatology, with the most common syndromes being progressive supranuclear palsy-Richardson's and corticobasal syndrome. Despite the lack of effective disease-modifying therapies, targeted treatment of symptoms can improve quality of life for patients with 4-repeat tauopathies. However, managing these symptoms can be a daunting task, even for those familiar with the diseases, as they span motor, sensory, cognitive, affective, autonomic, and behavioral domains. This review describes current approaches to symptomatic management of common clinical symptoms in 4-repeat tauopathies with a focus on practical patient management, including pharmacologic and nonpharmacologic strategies, and concludes with a discussion of the history and future of disease-modifying therapeutics and clinical trials in this population.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disease Management
/
Tauopathies
/
Motor Disorders
Type of study:
Prognostic_studies
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
Neurotherapeutics
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Estados Unidos