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Interfering with S100B-effector protein interactions for cancer therapy.
Wu, Ke-Jia; Wang, Wanhe; Wang, Hui-Min David; Leung, Chung-Hang; Ma, Dik-Lung.
Affiliation
  • Wu KJ; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa 999078, Macao SAR, China.
  • Wang W; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong 999077, Hong Kong, China.
  • Wang HD; Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
  • Leung CH; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa 999078, Macao SAR, China. Electronic address: duncanleung@um.edu.mo.
  • Ma DL; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong 999077, Hong Kong, China. Electronic address: edmondma@hkbu.edu.hk.
Drug Discov Today ; 25(9): 1754-1761, 2020 09.
Article in En | MEDLINE | ID: mdl-32679172
S100 calcium-binding protein B (S100B) is overexpressed in various malignant tumors, where it regulates cancer cell proliferation and metabolism by physical interactions with other molecules. Interfering with S100B-effector protein interactions is a potential strategy to treat malignant tumors. Although some S100B inhibitors have been discovered by virtual screening (VS), most target the S100B-p53 interaction. Hence, there is scope for the discovery of other S100B-effector protein interaction modulators for malignant tumors. In this review, we provide an overview of S100B-effector protein interaction inhibitor discovery using VS and discuss promising S100B-effector protein interaction targets that permit in silico analysis for drug discovery.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: S100 Calcium Binding Protein beta Subunit / Neoplasms Limits: Humans Language: En Journal: Drug Discov Today Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2020 Document type: Article Affiliation country: China Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: S100 Calcium Binding Protein beta Subunit / Neoplasms Limits: Humans Language: En Journal: Drug Discov Today Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2020 Document type: Article Affiliation country: China Country of publication: Reino Unido