From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.
Annu Rev Microbiol
; 74: 607-631, 2020 09 08.
Article
in En
| MEDLINE
| ID: mdl-32689917
ABSTRACT
Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of bacterial biofilms has been the subject of study in many organisms. Over the last two decades, the mechanisms of Pseudomonas fluorescens biofilm formation and regulation have emerged as among the best understood of any bacterial biofilm system. Biofilm formation by P. fluorescens occurs through the localization of an adhesin, LapA, to the outer membrane via a variant of the classical type I secretion system. The decision between biofilm formation and dispersal is mediated by LapD, a c-di-GMP receptor, and LapG, a periplasmic protease, which together control whether LapA is retained or released from the cell surface. LapA localization is also controlled by a complex network of c-di-GMP-metabolizing enzymes. This review describes the current understanding of LapA-mediated biofilm formation by P. fluorescens and discusses several emerging models for the regulation and function of this adhesin.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Pseudomonas fluorescens
/
Gene Expression Regulation, Bacterial
/
Cyclic GMP
/
Biofilms
Type of study:
Prognostic_studies
Language:
En
Journal:
Annu Rev Microbiol
Year:
2020
Document type:
Article
Affiliation country:
Estados Unidos