A Novel Etiology of Hypophysitis: Immune Checkpoint Inhibitors.
Endocrinol Metab Clin North Am
; 49(3): 387-399, 2020 09.
Article
in En
| MEDLINE
| ID: mdl-32741478
ABSTRACT
Checkpoint inhibitors trigger an immune process against cancer cells while causing cytotoxicity and self-antibody production against normal cells. Hypophysitis is a common endocrine toxicity. Hypophysitis may occur at any time during and after therapy, necessitating close clinical monitoring and screening for pituitary deficiencies. Treatment with high-dose glucocorticoids and temporary cessation of immunotherapy is indicated for severe hypophysitis with intractable headaches and vision changes, and for adrenal crisis. Increased awareness about this novel hypophysitis and multidisciplinary collaboration are needed to improve outcomes. This article reviews the function of immune checkpoint inhibitors and pituitary adverse effects with immune checkpoint inhibitor use.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hypophysitis
/
Immune Checkpoint Inhibitors
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Endocrinol Metab Clin North Am
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2020
Document type:
Article
Affiliation country:
Estados Unidos