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Extraction, purification, and determination of the gastroprotective activity of glucomannan from Bletilla striata.
Wang, Bulei; Zhang, Hui; Chen, Lijun; Mi, Zeyuan; Xu, Yan; Zhao, Guangming; Liu, Shuai; Lei, Hui; Wang, Zhezhi; Niu, Junfeng.
Affiliation
  • Wang B; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Zhang H; Shaanxi Pharmaceutical Holding Group PAIANG Chinese Medicine Co., Xi'an, 110026, PR China.
  • Chen L; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Mi Z; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Xu Y; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Zhao G; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Liu S; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Lei H; Biology Department, Xinzhou Teachers University, Xinzhou, 034000, PR China.
  • Wang Z; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China.
  • Niu J; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, PR China. Electronic a
Carbohydr Polym ; 246: 116620, 2020 Oct 15.
Article in En | MEDLINE | ID: mdl-32747259
ABSTRACT
In this study, a water-soluble polysaccharide (BSP) was extracted and purified from pseudobulb of Bletilla striata. The preliminary structure and gastroprotective activity of BSP were analyzed. Results indicate that BSP is a glucomannan with a molar ratio of 7.452.55 (ManGlc), and its molecular weight is approximately 1.7 × 105 Da. BSP displayed outstanding protective action against ethanol-induced GES-1 cell injury in vitro, as well as, excellent gastroprotective activity in vivo. Especially, a high-dose of BSP (100 mg/kg) could reduce the ulcer index of the gastric mucosa and increase the percentage of ulcer inhibition, which possibly caused by enhancing the antioxidant capacity and inhibiting the apoptotic pathway in gastric tissue. Interestingly, BSP exhibited a comparative gastroprotective activity to that of positive control (omeprazole). In summary, our results indicated that BSP could be considered as a potential supplement for the prevention of gastric injury.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Ulcer / Gastrointestinal Agents / Orchidaceae / Gastric Mucosa / Mannans / Antioxidants Language: En Journal: Carbohydr Polym Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Ulcer / Gastrointestinal Agents / Orchidaceae / Gastric Mucosa / Mannans / Antioxidants Language: En Journal: Carbohydr Polym Year: 2020 Document type: Article