A neglected cause of recurrent rhabdomyolysis, LPIN1 gene defect: a rare case from Turkey.
Turk J Pediatr
; 62(4): 647-651, 2020.
Article
in En
| MEDLINE
| ID: mdl-32779418
ABSTRACT
BACKGROUND:
Rhabdomyolysis; can occur due to toxic, infectious, metabolic, and genetic causes. Severe rhabdomyolysis may progress to several clinical manifestations such as cardiac arrest and may pose a risk of mortality if it is not treated timely. CASE In this article, we presented a 26-month-old patient who was admitted with an acute rhabdomyolysis attack and a venovenous hemodiafiltration (CVVHDF) was initiated on the 5th hour of hospitalization. Creatine kinase (CK) levels of the patient continued to increase (max 943 452 IU/L) until the 5th day of treatment and hereafter began to decrease. As the common causes of rhabdomyolysis were excluded and the CK levels were the highest values reported in the literature, although, LPIN1 deficiency was the most suspected diagnosis, to facilitate the diagnostic procedures a whole-exome sequencing was performed. A homozygous [c.1696G > C p. (Asp566His)] mutation was detected on LPIN1 gene. This variant has not been described previously, however, when examined with programs such as SIFT and Mutation taster, it has been considered as pathogenic.CONCLUSION:
In the pediatric age group, especially in infants presenting with severe rhabdomyolysis, LPIN1 deficiency should also be considered; as early diagnosis and appropriate treatment may reduce mortality.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhabdomyolysis
/
Hemodiafiltration
Type of study:
Etiology_studies
/
Screening_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Country/Region as subject:
Asia
Language:
En
Journal:
Turk J Pediatr
Year:
2020
Document type:
Article