Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.

Gerstenberger, Brian S; Ambler, Catherine; Arnold, Eric P; Banker, Mary-Ellen; Brown, Matthew F; Clark, James D; Dermenci, Alpay; Dowty, Martin E; Fensome, Andrew; Fish, Susan; Hayward, Matthew M; Hegen, Martin; Hollingshead, Brett D; Knafels, John D; Lin, David W; Lin, Tsung H; Owen, Dafydd R; Saiah, Eddine; Sharma, Raman; Vajdos, Felix F; Xing, Li; Yang, Xiaojing; Yang, Xin; Wright, Stephen W

Gerstenberger, Brian S; Ambler, Catherine; Arnold, Eric P; Banker, Mary-Ellen; Brown, Matthew F; Clark, James D; Dermenci, Alpay; Dowty, Martin E; Fensome, Andrew; Fish, Susan; Hayward, Matthew M; Hegen, Martin; Hollingshead, Brett D; Knafels, John D; Lin, David W; Lin, Tsung H; Owen, Dafydd R; Saiah, Eddine; Sharma, Raman; Vajdos, Felix F; Xing, Li; Yang, Xiaojing; Yang, Xin; Wright, Stephen W.

Affiliation

Gerstenberger BS; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Ambler C; Pfizer Inc., Groton, Connecticut 06340, United States.
Arnold EP; Pfizer Inc., Groton, Connecticut 06340, United States.
Banker ME; Pfizer Inc., Groton, Connecticut 06340, United States.
Brown MF; Pfizer Inc., Groton, Connecticut 06340, United States.
Clark JD; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Dermenci A; Pfizer Inc., Groton, Connecticut 06340, United States.
Dowty ME; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Fensome A; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Fish S; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Hayward MM; Pfizer Inc., Groton, Connecticut 06340, United States.
Hegen M; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Hollingshead BD; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Knafels JD; Pfizer Inc., Groton, Connecticut 06340, United States.
Lin DW; Pfizer Inc., Groton, Connecticut 06340, United States.
Lin TH; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Owen DR; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Saiah E; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Sharma R; Pfizer Inc., Groton, Connecticut 06340, United States.
Vajdos FF; Pfizer Inc., Groton, Connecticut 06340, United States.
Xing L; Pfizer Inc., Cambridge, Massachusetts 02139, United States.
Yang X; Pfizer Inc., Groton, Connecticut 06340, United States.
Yang X; Pfizer Inc., Groton, Connecticut 06340, United States.
Wright SW; Pfizer Inc., Groton, Connecticut 06340, United States.

J Med Chem ; 63(22): 13561-13577, 2020 11 25.

Article in En | MEDLINE | ID: mdl-32787094

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Protein Kinase Inhibitors / TYK2 Kinase / Drug Discovery Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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