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Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors.
Nakamura, Sho; Sayama, Misa; Uwamizu, Akiharu; Jung, Sejin; Ikubo, Masaya; Otani, Yuko; Kano, Kuniyuki; Omi, Jumpei; Inoue, Asuka; Aoki, Junken; Ohwada, Tomohiko.
Affiliation
  • Nakamura S; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Sayama M; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Uwamizu A; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Jung S; Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
  • Ikubo M; AMED-LEAP, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan.
  • Otani Y; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Kano K; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Omi J; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Inoue A; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Aoki J; Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
  • Ohwada T; AMED-LEAP, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan.
J Med Chem ; 63(17): 9990-10029, 2020 09 10.
Article in En | MEDLINE | ID: mdl-32787112
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lysophospholipids / Receptors, Purinergic P2 / Receptors, Lysophospholipid / Purinergic P2 Receptor Agonists Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lysophospholipids / Receptors, Purinergic P2 / Receptors, Lysophospholipid / Purinergic P2 Receptor Agonists Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos