Evaluation of belimumab treatment in patients with systemic lupus erythematosus in a clinical practice setting: Results from a 24-month OBSErve study in Argentina.
Lupus
; 29(11): 1385-1396, 2020 Oct.
Article
in En
| MEDLINE
| ID: mdl-32791930
ABSTRACT
OBJECTIVE:
To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice in Argentina.METHODS:
This retrospective, observational study analysed medical record data of patients with SLE treated with belimumab in 15 centres in Argentina. Primary endpoint overall clinical response (assessed on a scale similar to the 6-point Physician Global Assessment) at months 6, 12, 18 and 24, all versus index (belimumab initiation). Secondary endpoints improvement in disease activity (SELENA-SLEDAI), SLE manifestations, and corticosteroid dose change.RESULTS:
Records for 81 patients (91% female) were analysed. Clinical improvements were reported for 95%, 95%, 98% and 100% patients at 6, 12, 18, and 24 months post index, respectively. Mean SELENA-SLEDAI score decreased from 11.21 at index to 4.76, 3.77, 3.86 and 2.17 at 6, 12, 18, and 24 months post index, respectively. Number of flares decreased from 1.05 at index to 0.21, 0.09, 0.22 and 0.30 at 6, 12, 18, and 24 months post index, respectively. Mean corticosteroid dose was 14.59 mg/day at index, and 6.45, 5.18, 5.17 and 4.78 mg/day at 6, 12, 18, and 24 months post index, respectively.CONCLUSIONS:
Real-world patients with SLE treated with belimumab in Argentina demonstrated clinical improvements and reductions in corticosteroid dose.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Treatment Outcome
/
Adrenal Cortex Hormones
/
Antibodies, Monoclonal, Humanized
/
Immunosuppressive Agents
/
Lupus Erythematosus, Systemic
Type of study:
Evaluation_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Argentina
Language:
En
Journal:
Lupus
Journal subject:
REUMATOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Argentina