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Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics.
Gordon, Renata E; Nemeth, Jennifer F; Singh, Sanjaya; Lingham, Russell B; Grewal, Iqbal S.
Affiliation
  • Gordon RE; Janssen Biotherapeutics, The Janssen Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA.
  • Nemeth JF; Janssen Biotherapeutics, The Janssen Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA.
  • Singh S; Janssen Biotherapeutics, The Janssen Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA.
  • Lingham RB; Janssen Biotherapeutics, The Janssen Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA.
  • Grewal IS; Janssen Biotherapeutics, The Janssen Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA. Electronic address: igrewal@its.jnj.com.
Trends Biotechnol ; 39(3): 298-310, 2021 03.
Article in En | MEDLINE | ID: mdl-32807530
Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to deliver highly specific therapeutic antibodies intracellularly. Historically, antibodies have not been believed to traverse the cell membrane and neutralize intracellular targets. Emerging evidence has revealed that anti-DNA autoantibodies found in systemic lupus erythematosus (SLE) patients can penetrate inside the cell. Harnessing this technology has the potential to accelerate the development of drugs against intracellular targets. Here, we dissect the mechanisms of the intracellular localization of SLE antibodies and discuss how to apply these insights to engineer successful cell-penetrating antibody drugs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Antibodies, Antinuclear / Drug Delivery Systems / Lupus Erythematosus, Systemic Limits: Humans Language: En Journal: Trends Biotechnol Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Antibodies, Antinuclear / Drug Delivery Systems / Lupus Erythematosus, Systemic Limits: Humans Language: En Journal: Trends Biotechnol Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido