Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics.
Trends Biotechnol
; 39(3): 298-310, 2021 03.
Article
in En
| MEDLINE
| ID: mdl-32807530
Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to deliver highly specific therapeutic antibodies intracellularly. Historically, antibodies have not been believed to traverse the cell membrane and neutralize intracellular targets. Emerging evidence has revealed that anti-DNA autoantibodies found in systemic lupus erythematosus (SLE) patients can penetrate inside the cell. Harnessing this technology has the potential to accelerate the development of drugs against intracellular targets. Here, we dissect the mechanisms of the intracellular localization of SLE antibodies and discuss how to apply these insights to engineer successful cell-penetrating antibody drugs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Products
/
Antibodies, Antinuclear
/
Drug Delivery Systems
/
Lupus Erythematosus, Systemic
Limits:
Humans
Language:
En
Journal:
Trends Biotechnol
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido