The effect of oral Δ-9-tetrahydrocannabinol on the minimal alveolar concentration of sevoflurane: A randomised, controlled, observer-blinded experimental study.
Eur J Anaesthesiol
; 38(1): 58-63, 2021 01.
Article
in En
| MEDLINE
| ID: mdl-32833854
ABSTRACT
BACKGROUND:
Cannabis has increasingly been used for medical and recreational purposes. The main pharmacological compound in cannabis is tetrahydrocannabinol (THC), which has sedative, anxiolytic and analgesic effects. In some animal models, THC has also been shown to reduce the minimum alveolar concentration (MAC) of halothane and cyclopropane, but its effect on sevoflurane, currently the most commonly used inhalational anaesthetic agent, has not been investigated.OBJECTIVE:
To investigate the effect of THC on the MAC of sevoflurane in rats.METHODS:
Observer-blinded, randomised controlled trial.SETTING:
Centre for Biomedical Research of the Medical University of Vienna, 2019. INDIVIDUALS Thirty-eight adult Wistar rats.INTERVENTIONS:
The rats were allocated randomly into one of two groups. Group A received THC 10âmgâkg and group B received the corresponding volume of placebo via gastric gavage (administration through a tube placed in the distal oesophagus). The rats were then individually anaesthetised in an airtight sevoflurane-flooded chamber, and the MAC in both groups was determined using Dixon's up-and-down method. Blood samples were drawn to measure serum concentrations of THC. MAIN OUTCOMEMEASURES:
The primary outcome was the MAC of sevoflurane in Groups A and B.RESULTS:
The bootstrap estimate of the MAC of sevoflurane was 2.1 (95% confidence interval 1.8 to 2.4)âvol% in the THC group and 2.8 (95% confidence interval 2.7 to 2.9)âvol% in the placebo group, corresponding to a significant MAC reduction of 26% in response to THC.CONCLUSION:
Gastric administration of THC 10âmgâkg significantly reduced the MAC of sevoflurane by 26%. TRIAL REGISTRATION Not applicable.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anesthetics, Inhalation
/
Methyl Ethers
Limits:
Animals
Language:
En
Journal:
Eur J Anaesthesiol
Journal subject:
ANESTESIOLOGIA
Year:
2021
Document type:
Article