ROS-mediated synthetic growth defect caused by impaired metabolism of sphingolipids and phosphatidylserine in budding yeast.
Biosci Biotechnol Biochem
; 84(12): 2529-2532, 2020 Dec.
Article
in En
| MEDLINE
| ID: mdl-32842901
ABSTRACT
Previously, we found that yeast exhibits a strong growth defect with the combination of a lack of gene involved in structural modification of sphingolipids and repression of the phosphatidylserine synthase gene. Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphatidylserines
/
Sphingolipids
/
Reactive Oxygen Species
/
Saccharomycetales
Language:
En
Journal:
Biosci Biotechnol Biochem
Journal subject:
BIOQUIMICA
/
BIOTECNOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Japón