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Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation.
Kamata-Sakurai, Mika; Narita, Yoshinori; Hori, Yuji; Nemoto, Takayuki; Uchikawa, Ryo; Honda, Masaki; Hironiwa, Naoka; Taniguchi, Kenji; Shida-Kawazoe, Meiri; Metsugi, Shoichi; Miyazaki, Taro; Wada, Naoko A; Ohte, Yuki; Shimizu, Shun; Mikami, Hirofumi; Tachibana, Tatsuhiko; Ono, Natsuki; Adachi, Kenji; Sakiyama, Tetsushi; Matsushita, Tomochika; Kadono, Shojiro; Komatsu, Shun-Ichiro; Sakamoto, Akihisa; Horikawa, Sayuri; Hirako, Ayano; Hamada, Koki; Naoi, Sotaro; Savory, Nasa; Satoh, Yasuko; Sato, Motohiko; Noguchi, Yuki; Shinozuka, Junko; Kuroi, Haruka; Ito, Ami; Wakabayashi, Tetsuya; Kamimura, Masaki; Isomura, Fumihisa; Tomii, Yasushi; Sawada, Noriaki; Kato, Atsuhiko; Ueda, Otoya; Nakanishi, Yoshito; Endo, Mika; Jishage, Kou-Ichi; Kawabe, Yoshiki; Kitazawa, Takehisa; Igawa, Tomoyuki.
Affiliation
  • Kamata-Sakurai M; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan. mika.sakurai22@chugai-pharm.co.jp.
  • Narita Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Hori Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Nemoto T; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Uchikawa R; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Honda M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Hironiwa N; Chugai Pharmabody Research Pte. Ltd., Synapse, Singapore.
  • Taniguchi K; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Shida-Kawazoe M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Metsugi S; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Miyazaki T; Clinical Development Division, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
  • Wada NA; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Ohte Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Shimizu S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Mikami H; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Tachibana T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Ono N; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Adachi K; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Sakiyama T; Pharmaceutical Technology Division, Chugai Pharmaceutical Co., Ltd., Kita-ku, Tokyo, Japan.
  • Matsushita T; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Kadono S; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Komatsu SI; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Sakamoto A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Horikawa S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Hirako A; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Hamada K; Translational Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Naoi S; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Savory N; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Satoh Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Sato M; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Noguchi Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Shinozuka J; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Kuroi H; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Ito A; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Wakabayashi T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Kamimura M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Isomura F; Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa, Japan.
  • Tomii Y; Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan.
  • Sawada N; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Kato A; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Ueda O; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Nakanishi Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Endo M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Jishage KI; Project & Lifecycle Management Unit, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan.
  • Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan.
  • Kitazawa T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan.
  • Igawa T; Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa, Japan.
Cancer Discov ; 11(1): 158-175, 2021 01.
Article in En | MEDLINE | ID: mdl-32847940
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Triphosphate / Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Discov Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Triphosphate / Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Discov Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos