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Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity.
Paul, Ashim; Huber, Adi; Rand, Daniel; Gosselet, Fabien; Cooper, Itzik; Gazit, Ehud; Segal, Daniel.
Affiliation
  • Paul A; Department of Molecular Microbiology and Biotechnology, School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv, 6997801, Israel.
  • Huber A; Department of Molecular Microbiology and Biotechnology, School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv, 6997801, Israel.
  • Rand D; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel.
  • Gosselet F; UR 2465, Blood-brain barrier Laboratory (LBHE), Artois University, 62300, Lens, France.
  • Cooper I; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel.
  • Gazit E; Department of Molecular Microbiology and Biotechnology, School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv, 6997801, Israel.
  • Segal D; Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv, 6997801, Israel.
Chemistry ; 26(69): 16486-16496, 2020 Dec 09.
Article in En | MEDLINE | ID: mdl-32870550
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Naphthoquinones / Alpha-Synuclein / Amyloid Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Israel Country of publication: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Naphthoquinones / Alpha-Synuclein / Amyloid Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Israel Country of publication: Alemania