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Engineered Fc-glycosylation switch to eliminate antibody effector function.
Zhou, Qun; Jaworski, Julie; Zhou, Yanfeng; Valente, Delphine; Cotton, Joanne; Honey, Denise; Boudanova, Ekaterina; Beninga, Jochen; Rao, Ercole; Wei, Ronnie; Mauriac, Christine; Pan, Clark; Park, Anna; Qiu, Huawei.
Affiliation
  • Zhou Q; Biologics Research, Sanofi , Framingham, MA, USA.
  • Jaworski J; Biologics Research, Sanofi , Framingham, MA, USA.
  • Zhou Y; Biologics Research, Sanofi , Framingham, MA, USA.
  • Valente D; DMPK, Sanofi , Vitry-Sur-Seine, France.
  • Cotton J; Biologics Development, Sanofi , Framingham, MA, USA.
  • Honey D; Biologics Research, Sanofi , Framingham, MA, USA.
  • Boudanova E; Biologics Research, Sanofi , Framingham, MA, USA.
  • Beninga J; Biologics Research, Sanofi , Frankfurt, Germany.
  • Rao E; Biologics Research, Sanofi , Frankfurt, Germany.
  • Wei R; Biologics Research, Sanofi , Framingham, MA, USA.
  • Mauriac C; DMPK, Sanofi , Vitry-Sur-Seine, France.
  • Pan C; Biologics Research, Sanofi , Framingham, MA, USA.
  • Park A; Biologics Research, Sanofi , Framingham, MA, USA.
  • Qiu H; Biologics Research, Sanofi , Framingham, MA, USA.
MAbs ; 12(1): 1814583, 2020.
Article in En | MEDLINE | ID: mdl-32892677
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fc Fragments / Receptors, Fc / Histocompatibility Antigens Class I / Complement Activation / Amino Acid Substitution / Mutation, Missense / Cytotoxicity, Immunologic Limits: Animals / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fc Fragments / Receptors, Fc / Histocompatibility Antigens Class I / Complement Activation / Amino Acid Substitution / Mutation, Missense / Cytotoxicity, Immunologic Limits: Animals / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos