Your browser doesn't support javascript.
loading
Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
Justice, Anne E; Chittoor, Geetha; Gondalia, Rahul; Melton, Phillip E; Lim, Elise; Grove, Megan L; Whitsel, Eric A; Liu, Ching-Ti; Cupples, L Adrienne; Fernandez-Rhodes, Lindsay; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Boerwinkle, Eric; Li, Yun; Demerath, Ellen; Heard-Costa, Nancy; Levy, Dan; Stewart, James D; Baccarelli, Andrea; Hou, Lifang; Conneely, Karen; Mori, Trevor A; Beilin, Lawrence J; Huang, Rae-Chi; Gordon-Larsen, Penny; Howard, Annie Green; North, Kari E.
Affiliation
  • Justice AE; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA.
  • Chittoor G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Gondalia R; Department of Population Health Sciences, Geisinger, Danville, PA 17822, USA.
  • Melton PE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Lim E; School of Biomedical Science, Faculty of Health & Medical Sciences, The University of Western Australia, Perth, WA 6000, Australia.
  • Grove ML; School of Pharmacy & Biomedical Sciences, Faculty of Health Sciences, Curtin University, MRF Building, Perth, WA 6000, Australia.
  • Whitsel EA; Menzies Institute for Medical Research, College of Health & Medicine, University of Tasmania, Hobart, TA, 7000 Australia.
  • Liu CT; Department of Biostatistics, Boston University, Boston, MA 02118, USA.
  • Cupples LA; Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Fernandez-Rhodes L; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Guan W; Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Bressler J; Department of Biostatistics, Boston University, Boston, MA 02118, USA.
  • Fornage M; Department of Biostatistics, Boston University, Boston, MA 02118, USA.
  • Boerwinkle E; Framingham Heart Study, Framingham, MA, 01701, USA.
  • Li Y; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Demerath E; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA.
  • Heard-Costa N; Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA.
  • Levy D; Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Stewart JD; Center for Human Genetics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Baccarelli A; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030, USA.
  • Hou L; Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Conneely K; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Mori TA; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Beilin LJ; Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA.
  • Huang RC; Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN 55455, USA.
  • Gordon-Larsen P; Framingham Heart Study, Framingham, MA, 01701, USA.
  • Howard AG; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA.
  • North KE; Population sciences branch, NHLBI Framingham Heart Study, Framingham, MA 01702, USA.
Epigenomics ; 12(17): 1483-1499, 2020 09.
Article in En | MEDLINE | ID: mdl-32901515
ABSTRACT

Aim:

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. Materials &

methods:

We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). Results &

conclusion:

We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Epigenesis, Genetic / Endocrine System / Adiposity / Epigenomics / Immune System Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Epigenomics Year: 2020 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Epigenesis, Genetic / Endocrine System / Adiposity / Epigenomics / Immune System Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Epigenomics Year: 2020 Document type: Article Affiliation country: Estados Unidos