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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
Gibson, Anna E; Yeung, Choh; Issaq, Sameer H; Collins, Victor J; Gouzoulis, Michael; Zhang, Yiping; Ji, Jiuping; Mendoza, Arnulfo; Heske, Christine M.
Affiliation
  • Gibson AE; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Yeung C; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Issaq SH; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Collins VJ; Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Gouzoulis M; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zhang Y; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Ji J; National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Mendoza A; National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Heske CM; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Oncogenesis ; 9(9): 80, 2020 Sep 10.
Article in En | MEDLINE | ID: mdl-32908120
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Oncogenesis Year: 2020 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Oncogenesis Year: 2020 Document type: Article Affiliation country: Estados Unidos