Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa.
Food Chem
; 339: 127985, 2021 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-32920305
ABSTRACT
There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal Microbial Ecosystem for the determination of pesticide residue bioaccessibility in Chaenomeles speciosa, and a Caco-2 cell model of human intestinal absorption. Results showed that gut microbiota played a dual role based their effects on contaminant release and metabolism in the bioaccessibility assay, and Lactobacillus plantarum was one of key bacterial species in the gut microbiota that influenced pesticide stability significantly. The addition of L. plantarum to the system reduced the relative amounts (by 11.40-86.51%) of six pesticides. The interaction between the food matrix and human gut microbiota led to different absorption rates, and the barrier effects increased with an increase in incubation time.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pesticides
/
Rosaceae
/
Gastrointestinal Microbiome
/
Intestinal Mucosa
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Food Chem
Year:
2021
Document type:
Article
Affiliation country:
China