Clinical features and prognosis of nocardiosis in patients with connective tissue diseases.
Mod Rheumatol
; 31(3): 636-642, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-32930047
ABSTRACT
OBJECTIVES:
To investigate the clinical features and prognosis of nocardiosis complicated by connective tissue diseases (CTDs).METHODS:
We examined patients with CTDs who were diagnosed with nocardiosis from October 2004 to 2019. We retrospectively investigated patient characteristics and therapeutic outcomes. We then performed a comparison between survivors and non-survivors.RESULTS:
Fourteen patients were examined. Underlying CTDs were systemic lupus erythematosus (28.6%), vasculitis syndrome (28.6%), rheumatoid arthritis (21.4%), adult Still disease (14.3%) and dermatomyositis (7.1%). Infected organs were lung (85.7%), brain (42.9%), skin/cutaneous lesions (28.6%) and muscle (7.1%). Disseminated infections were seen in nine patients (64.3%). At the onset of nocardiosis, all patients were given prednisolone (23.2 ± 11.9 mg/day). Only two patients (14.3%) were given TMP-SMX for prophylaxis of pneumocystis pneumonia. Relapse occurred in one patient (7.1%) and four patients (28.6%) died from nocardiosis for a cumulative survival rate at 52 weeks of 76.9%. In a comparison of survivors (71.4%) and non-survivors (28.6%), cutaneous lesions were significantly more frequent in the latter (10 vs 75%, p = .04) with an odds ratio of 27.0 (95% CI 1.7-453.4).CONCLUSION:
Cutaneous lesions as a result of dissemination might be a risk factor for nocardiosis mortality in patients with CTDs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Vasculitis
/
Trimethoprim, Sulfamethoxazole Drug Combination
/
Lupus Erythematosus, Systemic
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Anti-Bacterial Agents
/
Nocardia Infections
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Mod Rheumatol
Year:
2021
Document type:
Article
Affiliation country:
Japón