The cut-off value of a qualitative brain diffusion-weighted image (DWI) scoring system to predict poor neurologic outcome in out-of-hospital cardiac arrest (OHCA) patients after target temperature management.
Resuscitation
; 157: 202-210, 2020 12.
Article
in En
| MEDLINE
| ID: mdl-32931850
ABSTRACT
AIM:
We presented the cut-off value of a diffusion-weighted image (DWI) scoring system to predict poor neurologic outcome using DWI taken 72-96â¯h after out-of-hospital cardiac arrest (OHCA) patients underwent target temperature management (TTM).METHODS:
This was a prospective single-centre observational study, conducted from March 2018 to April 2020 in OHCA patients after TTM. Neurological status was assessed 6 months after return of spontaneous circulation (ROSC) using the Glasgow-Pittsburgh cerebral performance categories (CPC) scale. CPC of 1-2 demonstrated good neurologic outcomes whilst a CPC of 3-5 was related to poor neurologic outcomes. The receiver operating characteristic curves and DeLong method were used to evaluate the cut-off value of the DWI scoring system to predict poor neurologic outcome.RESULTS:
The good and poor neurologic outcome groups consisted of 38 (54.3%) and 32 (45.7%) patients, respectively. The area under the receiver operating characteristic curve (AUROC) of the overall, cortex, deep grey nuclei, and cortex plus deep grey nuclei scores, white matter, brainstem, and cerebellum measured 72-96â¯h after ROSC were 0.96, 0.96, 0.97, 0.96, 0.95, 0.95, and 0.93 respectively. For 100.0% specificity to predict poor neurologic outcome, the overall scores of the DWI scoring system measured 72-96â¯h after ROSC with a cut-off value of 52 had a sensitivity of 81.3% (95% CI 63.6-92.8).CONCLUSION:
This study demonstrated that the DWI scoring systems measured between 72 and 96â¯h after ROSC were valuable tools to predict poor neurologic outcome in post-OHCA patients treated with TTM.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Out-of-Hospital Cardiac Arrest
/
Hypothermia, Induced
Type of study:
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Resuscitation
Year:
2020
Document type:
Article