Four new sesquiterpene lactones from Atractylodes macrocephala and their CREB agonistic activities.
Fitoterapia
; 147: 104730, 2020 Nov.
Article
in En
| MEDLINE
| ID: mdl-32971205
ABSTRACT
One new bisesquiterpenoid, biepiasreorlid II (1), three new sesquiterpene lactones 8α-methoxy-epiasterolid (4), 3ß-acetoxyl-8-epiasterolid (5), and 3ß-acetoxyl-atractylenolide I (6), along with five known analogues (2-3 and 7-9), were obtained from rhizome of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by the analysis of single-crystal X-ray diffraction with Ga Kα radiation, and 4-6 were elucidated by TDDFT-ECD calculations. The CREB agonistic activity was investigated in HEK293T cells using dual luciferase reporter assay. Compounds 1, 2, 5, and 7-9 exhibited strong to agonistic activities on CREB.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Cyclic AMP Response Element-Binding Protein
/
Atractylodes
/
Lactones
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2020
Document type:
Article