Parity-related variation in cortisol concentrations in hair during pregnancy.
BJOG
; 128(4): 637-644, 2021 Mar.
Article
in En
| MEDLINE
| ID: mdl-32985075
ABSTRACT
OBJECTIVE:
To investigate hair cortisol concentrations (HCC) monthly in pregnant women and to explore the effect of parity.DESIGN:
Prospective cohort study from gestational week (GW) 26, at childbirth and postpartum.SETTING:
An antenatal care clinic in southeast Sweden. SAMPLE 390 pregnant women.METHODS:
Cortisol was measured using radioimmunoassay in methanol extracts of ground hair samples. MAIN OUTCOMEMEASURES:
Hair cortisol concentrations.RESULTS:
Both primi- and multiparae exhibited an increase in HCC throughout pregnancy. Primiparae had significantly higher HCC in the latter part of the last trimester compared with multiparae (1 month P = 0.003, 2 months P = 0.038). The use of psychotropic medication in the first trimester correlated to HCC postpartum (P < 0.001). HCC in GW 14-17 was associated with HCC in GW 18-21 (primiparae and multiparae, P < 0.001), GW 22-25 (primiparae P = 0.036, multiparae P = 0.033), and 2 months postpartum (primiparae P = 0.049). HCC in GW 18-21 was associated with GW 22-25 in both primiparae (P < 0.001) and multiparae (P < 0.001) as well as 2 months prior to childbirth among primiparae (<0.037). In general, all estimates of HCC in pregnancy and postpartum showed a significant association between HCC for a specific month and the HCC in the previous month (all P < 0.001), except for the association of HCC among primiparae in GW 22-25 and 3 months prior to childbirth.CONCLUSIONS:
Increased cortisol concentrations in hair were observed during pregnancy, which decreased 3 months prior to childbirth in multiparae. The results indicate a quicker suppression of the hypothalamic CRH (corticotropin-releasing hormone) production by placenta CRH in multiparous women. TWEETABLE ABSTRACT Multiparae have a quicker suppression of hypothalamic CRH production by placenta CRH during pregnancy compared to primiparae.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parity
/
Pituitary-Adrenal System
/
Pregnancy
/
Hydrocortisone
/
Hair
/
Hypothalamo-Hypophyseal System
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Language:
En
Journal:
BJOG
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2021
Document type:
Article
Affiliation country:
Suecia