Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis.
Biosci Rep
; 40(10)2020 10 30.
Article
in En
| MEDLINE
| ID: mdl-33026063
ABSTRACT
BACKGROUND:
Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.AIM:
To evaluate the relationship between ATL and IO in patients with HH.METHODS:
Cross-sectional study including 25 patients with HH 8 with IO and 17 without IO (ferritin < 300 ng/ml) and 25 healthy controls. Inclusion criteria were age > 18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.RESULTS:
HH patients with IO were older (P<0.001) and showed higher ferritin concentration (P<0.001). Patients with HH, disregarding the iron status, showed higher glucose and body mass index (BMI) than controls (both P<0.01). ATL was shorter in patients with IO than controls [with IO 8 (6-14), without IO 13 (9-20), and controls 19 (15-25) kilobase pairs, P<0.01]; with a linear trend within groups (P for trend <0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose (P<0.05).DISCUSSION:
Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Telomere
/
Telomere Homeostasis
/
Hemochromatosis
/
Iron
/
Leukocytes
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Biosci Rep
Year:
2020
Document type:
Article
Affiliation country:
Argentina