Environmental pollutants: an immunoendocrine perspective on phthalates.
Front Biosci (Landmark Ed)
; 26(3): 401-430, 2021 01 01.
Article
in En
| MEDLINE
| ID: mdl-33049675
Phthalates are endocrine disrupting compounds (EDCs) used as plasticizers in a wide array of daily-use products, from flooring and automotive parts to medical devices and are even present in the children�s toys. Since these compounds are not covalently bound other molecules, they leach from these synthetic products, causing a high level of human exposure to them. EDCs exert several endocrine effects, most typically, reduced biosynthesis of the male hormone, testosterone and disturbances in estrogen, androgen, PPAR-gamma and AhR that control complex immunoendocrine regulatory networks. Besides impacting the developmental processes and long-term adverse effects, since cells of the immune system express endocrine receptors, and synthetize and respond to several hormones and other endocrine ligands, phthalates also cause dysregulation of immune system.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phthalic Acids
/
Endocrine System
/
Environmental Pollutants
/
Immune System
Limits:
Humans
Language:
En
Journal:
Front Biosci (Landmark Ed)
Year:
2021
Document type:
Article
Affiliation country:
México
Country of publication:
Singapur