Four-component Meningococcal Serogroup B Vaccine Induces Antibodies With Bactericidal Activity Against Diverse Outbreak Strains in Adolescents.
Pediatr Infect Dis J
; 40(2): e66-e71, 2021 02 01.
Article
in En
| MEDLINE
| ID: mdl-33060520
ABSTRACT
BACKGROUND:
Neisseria meningitidis serogroup B (MenB) causes most meningitis outbreaks worldwide. We evaluated the ability of the 4-component MenB vaccine (4CMenB) to induce bactericidal activity against outbreak strains in adolescents.METHODS:
Individual sera from 20 United States and 23 Chilean adolescents who received 2 doses of 4CMenB 2 months apart were assayed at prevaccination and 1 month after second dose using a human complement serum bactericidal antibody assay (hSBA) against a full or subset strain panel consisting of 14 MenB outbreak strains and 1 MenW hyperendemic strain collected between 2001 and 2017 in the United States, United Kingdom, and France. Bactericidal activity was determined as the percentage of adolescents with hSBA titer ≥14 or ≥18.RESULTS:
One month after the second 4CMenB dose, antibodies from 65% to 100% of the US adolescents were able to kill 12 of 15 strains at 14 dilution. The remaining 3 strains were killed by 45%, 25%, and 15% of US adolescent sera. Similar percentages exhibited hSBA titers of ≥18. Across a subset of 4 strains, point estimates for the percentages of Chilean and US adolescents with hSBA titers of ≥14 after the second 4CMenB dose were similar (100% for strain M27703, 74% vs. 80% for M26312, 52% vs. 45% for M08 0240745), except for strain M39090 (91% vs. 65%).CONCLUSIONS:
This study was the first to evaluate bactericidal activity elicited by a MenB vaccine against 15 outbreak strains. Two doses of 4CMenB elicited bactericidal activity against MenB outbreak strains and a hyperendemic MenW strain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Meningococcal Vaccines
/
Neisseria meningitidis, Serogroup B
/
Meningococcal Infections
/
Antibodies, Bacterial
/
Antigens, Bacterial
Type of study:
Clinical_trials
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
America do norte
/
America do sul
/
Chile
/
Europa
Language:
En
Journal:
Pediatr Infect Dis J
Journal subject:
DOENCAS TRANSMISSIVEIS
/
PEDIATRIA
Year:
2021
Document type:
Article
Affiliation country:
Italia