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An Open Resource for Non-human Primate Optogenetics.
Tremblay, Sébastien; Acker, Leah; Afraz, Arash; Albaugh, Daniel L; Amita, Hidetoshi; Andrei, Ariana R; Angelucci, Alessandra; Aschner, Amir; Balan, Puiu F; Basso, Michele A; Benvenuti, Giacomo; Bohlen, Martin O; Caiola, Michael J; Calcedo, Roberto; Cavanaugh, James; Chen, Yuzhi; Chen, Spencer; Chernov, Mykyta M; Clark, Andrew M; Dai, Ji; Debes, Samantha R; Deisseroth, Karl; Desimone, Robert; Dragoi, Valentin; Egger, Seth W; Eldridge, Mark A G; El-Nahal, Hala G; Fabbrini, Francesco; Federer, Frederick; Fetsch, Christopher R; Fortuna, Michal G; Friedman, Robert M; Fujii, Naotaka; Gail, Alexander; Galvan, Adriana; Ghosh, Supriya; Gieselmann, Marc Alwin; Gulli, Roberto A; Hikosaka, Okihide; Hosseini, Eghbal A; Hu, Xing; Hüer, Janina; Inoue, Ken-Ichi; Janz, Roger; Jazayeri, Mehrdad; Jiang, Rundong; Ju, Niansheng; Kar, Kohitij; Klein, Carsten; Kohn, Adam.
Affiliation
  • Tremblay S; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: strem@pennmedicine.upenn.edu.
  • Acker L; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Afraz A; National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
  • Albaugh DL; Yerkes National Primate Research Center, Morris K. Udall Center of Excellence for Parkinson's Disease, Department of Neurology, Emory University, GA 30329, USA.
  • Amita H; Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Andrei AR; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas-Houston, Houston, TX 77030, USA.
  • Angelucci A; Department of Ophthalmology, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA.
  • Aschner A; Dominik P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Balan PF; Laboratory of Neuro- and Psychophysiology, KU Leuven, 3000 Leuven, Belgium.
  • Basso MA; Departments of Psychiatry and Biobehavioral Sciences and Neurobiology, UCLA, Los Angeles, CA 90095, USA.
  • Benvenuti G; Departments of Psychology and Neuroscience, Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA.
  • Bohlen MO; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
  • Caiola MJ; Yerkes National Primate Research Center, Morris K. Udall Center of Excellence for Parkinson's Disease, Department of Neurology, Emory University, GA 30329, USA.
  • Calcedo R; Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19014, USA.
  • Cavanaugh J; Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20982, USA.
  • Chen Y; Departments of Psychology and Neuroscience, Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA.
  • Chen S; Departments of Psychology and Neuroscience, Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA.
  • Chernov MM; Division of Neuroscience, Oregon National Primate Resource Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
  • Clark AM; Department of Ophthalmology, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA.
  • Dai J; CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen 518055, China.
  • Debes SR; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas-Houston, Houston, TX 77030, USA.
  • Deisseroth K; Neuroscience Program, Departments of Bioengineering, Psychiatry, and Behavioral Science, Wu Tsai Neurosciences Institute, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
  • Desimone R; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Dragoi V; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas-Houston, Houston, TX 77030, USA.
  • Egger SW; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Eldridge MAG; Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
  • El-Nahal HG; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
  • Fabbrini F; Laboratory of Neuro- and Psychophysiology, KU Leuven, 3000 Leuven, Belgium; Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium.
  • Federer F; Department of Ophthalmology, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA.
  • Fetsch CR; The Solomon H. Snyder Department of Neuroscience & Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Fortuna MG; German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Friedman RM; Division of Neuroscience, Oregon National Primate Resource Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
  • Fujii N; Laboratory for Adaptive Intelligence, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
  • Gail A; German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany; Bernstein Center for Computational Neuroscience, Göttingen, Germany; Faculty for Biology and Psychology, University of Göttingen, Göttingen, Germany; Leibniz Science Campus Primate Cognition, Göttingen, Germany
  • Galvan A; Yerkes National Primate Research Center, Morris K. Udall Center of Excellence for Parkinson's Disease, Department of Neurology, Emory University, GA 30329, USA.
  • Ghosh S; Department of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637, USA.
  • Gieselmann MA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle NE2 4HH, UK.
  • Gulli RA; Zuckerman Institute, Columbia University, New York, NY 10027, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY 10027, USA.
  • Hikosaka O; Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Hosseini EA; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Hu X; Yerkes National Primate Research Center, Morris K. Udall Center of Excellence for Parkinson's Disease, Department of Neurology, Emory University, GA 30329, USA.
  • Hüer J; German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Inoue KI; Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan; PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
  • Janz R; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas-Houston, Houston, TX 77030, USA.
  • Jazayeri M; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Jiang R; School of Life Sciences, Peking University, Beijing 100871, China.
  • Ju N; School of Life Sciences, Peking University, Beijing 100871, China.
  • Kar K; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Klein C; Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
  • Kohn A; Dominik P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Systems and Computational Biology, Albert Einstein College of Medicine,
Neuron ; 108(6): 1075-1090.e6, 2020 12 23.
Article in En | MEDLINE | ID: mdl-33080229
ABSTRACT
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Primates / Brain / Optogenetics / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2020 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Primates / Brain / Optogenetics / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2020 Document type: Article