Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis.
Mult Scler J Exp Transl Clin
; 6(4): 2055217320964502, 2020.
Article
in En
| MEDLINE
| ID: mdl-33110618
ABSTRACT
In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods:
Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results,Conclusion:
In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = -2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Journal:
Mult Scler J Exp Transl Clin
Year:
2020
Document type:
Article
Affiliation country:
Estados Unidos