Every minute counts: in-hospital changes of left ventricular regional and global function in patients with ST-segment elevation myocardial infarction.
J Cardiovasc Med (Hagerstown)
; 22(5): 363-370, 2021 May 01.
Article
in En
| MEDLINE
| ID: mdl-33136804
ABSTRACT
AIMS:
The aim of our study was to assess the effects of an early percutaneous coronary intervention on changes of in-hospital left ventricular ejection fraction (LVEF) and wall motion score index (WMSI) in patients with ST-segment elevation myocardial infarction.METHODS:
The study population consisted of 324 consecutive patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention, divided into two groups, according to the first medical contact (FMC)-to-reperfusion time, respectively, 90âmin or less (nâ=â173) and more than 90âmin (nâ=â151). Moreover, we performed a sub-analysis in the group of patients who showed at discharge an improvement in the LVEF of at least 10%.RESULTS:
In both groups at baseline, patients suffered from a moderately reduced LVEF (40.88â±â8.38% in ≤90âmin group vs. 40.70â±â8.98% in >90âmin group; Pâ=â0.858). A WMSI of more than 1 was recorded uniformly 1.71â±â0.37 in patients with FMC-to-reperfusion 90âmin or less and 1.72â±â0.38 in patients more than 90âmin (Pâ=â0.810). At the time of discharge, a significant improvement in LVEF (43.82â±â8.38%, Pâ=â0.001) and WMSI (1.60â±â0.41, Pâ=â0.009) exclusively emerged in the 90âmin or less group. Furthermore, we identified 105 patients who experienced an improvement in the LVEF of at least 10% compared with baseline values. In these patients FMC-to-reperfusion and total ischemic time resulted as significantly shorter, when compared with patients with LVEF improvement of less than 10%.CONCLUSION:
Our study confirms and reinforces the concept that reducing the duration of the time between FMC and reperfusion, as well as the total ischemic time influences a positive recovery of left ventricular global and regional function during in-hospital stay.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stroke Volume
/
Recovery of Function
/
Time-to-Treatment
/
Percutaneous Coronary Intervention
/
ST Elevation Myocardial Infarction
/
Hospitalization
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Cardiovasc Med (Hagerstown)
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2021
Document type:
Article