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EOS789, a broad-spectrum inhibitor of phosphate transport, is safe with an indication of efficacy in a phase 1b randomized crossover trial in hemodialysis patients.
Hill Gallant, Kathleen M; Stremke, Elizabeth R; Trevino, Laurie L; Moorthi, Ranjani N; Doshi, Simit; Wastney, Meryl E; Hisada, Nozomi; Sato, Jotaro; Ogita, Yoshitaka; Fujii, Naohisa; Matsuda, Yuya; Kake, Takei; Moe, Sharon M.
Affiliation
  • Hill Gallant KM; Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA; Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Stremke ER; Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA.
  • Trevino LL; Clinical Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Moorthi RN; Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Doshi S; Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Wastney ME; Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA; Metabolic Modeling Services, West Lafayette, Indiana, USA.
  • Hisada N; Chugai Pharmaceutical Co., Tokyo, Japan.
  • Sato J; Chugai Pharmaceutical Co., Tokyo, Japan.
  • Ogita Y; Chugai Pharmaceutical Co., Tokyo, Japan.
  • Fujii N; Chugai Pharmaceutical Co., Tokyo, Japan.
  • Matsuda Y; Chugai Pharmaceutical Co., Tokyo, Japan.
  • Kake T; Chugai Pharmaceutical Co., Tokyo, Japan.
  • Moe SM; Clinical Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA; Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: smoe@iu.edu.
Kidney Int ; 99(5): 1225-1233, 2021 05.
Article in En | MEDLINE | ID: mdl-33137340
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyamines / Hyperphosphatemia Type of study: Clinical_trials / Etiology_studies / Guideline Limits: Humans Language: En Journal: Kidney Int Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyamines / Hyperphosphatemia Type of study: Clinical_trials / Etiology_studies / Guideline Limits: Humans Language: En Journal: Kidney Int Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos