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Cocaine Reduces Ciliary Beat Frequency of Human Nasal Epithelial Cells.
Nastev, Alexander; Sommer, J Ulrich; Behr, Wieland; Stuck, Boris A; Mueller, C Emika; Schell, Angela; Kramer, Benedikt; Haeussler, Daniel; Hoermann, Karl; Birk, Richard.
Affiliation
  • Nastev A; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Sommer JU; Department of Otorhinolaryngology, Head and Neck Surgery, Helios University Hospital Wuppertal, Wuppertal, Germany.
  • Behr W; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Stuck BA; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Mueller CE; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Schell A; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
  • Kramer B; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
  • Haeussler D; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
  • Hoermann K; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
  • Birk R; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany richard.birk@staff.uni-marburg.de.
In Vivo ; 34(6): 3285-3289, 2020.
Article in En | MEDLINE | ID: mdl-33144435
ABSTRACT
BACKGROUND/

AIM:

Cocaine is a widely used recreational drug and is known for its nasal complications including epithelial, cartilage and bone damage. The aim of the study was to analyze the impact of cocaine on ciliary beat frequency (CBF) of human nasal epithelial cells and therefore better understand its side effects on nasal mucosa. MATERIALS AND

METHODS:

Nasal epithelial cells of 21 healthy subjects were harvested and exposed in vitro to cocaine hydrochloride solutions ranging from 0.875% to 7%. High-speed video footage was acquired with phase contrast microscopy and CBF was analyzed with Sissons-Ammons Video Analysis (SAVA) software.

RESULTS:

All tested concentrations led to a significant reduction in CBF compared to the control. Effects increased over time and with concentration. A mechanical inhibition of cilia by cocaine crystals was also observed.

CONCLUSION:

We assume that CBF reduction is part of the pathomechanism leading to nasal complications in cocaine abuse. Considering these results, clinical usage of cocaine should be critically evaluated and restricted to select cases only.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cocaine Limits: Humans Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2020 Document type: Article Affiliation country: Alemania
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cocaine Limits: Humans Language: En Journal: In Vivo Journal subject: NEOPLASIAS Year: 2020 Document type: Article Affiliation country: Alemania