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Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler, Felix A; Wang, Meng; Mu, Anfeng; Millington, Christopher L; Oberbeck, Nina; Watcham, Sam; Pontel, Lucas B; Kamimae-Lanning, Ashley N; Langevin, Frederic; Nadler, Camille; Cordell, Rebecca L; Monks, Paul S; Yu, Rui; Wilson, Nicola K; Hira, Asuka; Yoshida, Kenichi; Mori, Minako; Okamoto, Yusuke; Okuno, Yusuke; Muramatsu, Hideki; Shiraishi, Yuichi; Kobayashi, Masayuki; Moriguchi, Toshinori; Osumi, Tomoo; Kato, Motohiro; Miyano, Satoru; Ito, Etsuro; Kojima, Seiji; Yabe, Hiromasa; Yabe, Miharu; Matsuo, Keitaro; Ogawa, Seishi; Göttgens, Berthold; Hodskinson, Michael R G; Takata, Minoru; Patel, Ketan J.
Affiliation
  • Dingler FA; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Wang M; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK; Department of Haematology, University of Cambridge, Cambridge, UK.
  • Mu A; Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan; Department of Genome Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; Department of Clinical Application, Center for iPS Cell Research and Applicat
  • Millington CL; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Oberbeck N; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Watcham S; Department of Haematology, University of Cambridge, Cambridge, UK; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
  • Pontel LB; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET, Polo Científico Tecnológico, Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina.
  • Kamimae-Lanning AN; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Langevin F; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Nadler C; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Cordell RL; Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
  • Monks PS; Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
  • Yu R; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Wilson NK; Department of Haematology, University of Cambridge, Cambridge, UK; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
  • Hira A; Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan; Department of Genome Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
  • Yoshida K; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Mori M; Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan; Department of Genome Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto Uni
  • Okamoto Y; Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan; Department of Genome Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto Uni
  • Okuno Y; Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Muramatsu H; Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Shiraishi Y; Section of Genome Analysis Platform, Center for Cancer Genomic and Advanced Therapeutics, National Cancer Center, Tokyo, Japan.
  • Kobayashi M; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Hematology, Kyoto Katsura Hospital, Kyoto, Japan.
  • Moriguchi T; Department of Hematology, Kyoto Katsura Hospital, Kyoto, Japan.
  • Osumi T; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Kato M; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Miyano S; Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo Japan.
  • Ito E; Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
  • Kojima S; Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yabe H; Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.
  • Yabe M; Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.
  • Matsuo K; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan; Division of Analytical Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Sweden; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
  • Göttgens B; Department of Haematology, University of Cambridge, Cambridge, UK; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
  • Hodskinson MRG; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Takata M; Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan; Department of Genome Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan. Electronic address: takata.minoru.8s@kyoto-u.ac.jp.
  • Patel KJ; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. Electro
Mol Cell ; 80(6): 996-1012.e9, 2020 12 17.
Article in En | MEDLINE | ID: mdl-33147438
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Dehydrogenase / Leukemia / Aldehyde Dehydrogenase, Mitochondrial / Formaldehyde Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Dehydrogenase / Leukemia / Aldehyde Dehydrogenase, Mitochondrial / Formaldehyde Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos