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An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody-Drug Conjugates.
Merkul, Eugen; Muns, Joey A; Sijbrandi, Niels J; Houthoff, Hendrik-Jan; Nijmeijer, Bart; van Rheenen, Gerro; Reedijk, Jan; van Dongen, Guus A M S.
Affiliation
  • Merkul E; Chemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
  • Muns JA; Chemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
  • Sijbrandi NJ; Chemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
  • Houthoff HJ; Chemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
  • Nijmeijer B; Chemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
  • van Rheenen G; Chemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
  • Reedijk J; Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300, RA, Leiden, The Netherlands.
  • van Dongen GAMS; Department of Radiology and Nuclear Medicine, Amsterdam UMC, location VU medical center, Amsterdam, The Netherlands.
Angew Chem Int Ed Engl ; 60(6): 3008-3015, 2021 02 08.
Article in En | MEDLINE | ID: mdl-33185916
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / Immunoconjugates / Coordination Complexes / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2021 Document type: Article Affiliation country: Países Bajos Country of publication: Alemania
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platinum / Immunoconjugates / Coordination Complexes / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2021 Document type: Article Affiliation country: Países Bajos Country of publication: Alemania