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Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias, Anthony J; Kale, Abhijit; Perrone, Rosalba; Lopez-Dominguez, Jose Alberto; Pisco, Angela Oliveira; Kasler, Herbert G; Schmidt, Mark S; Heckenbach, Indra; Kwok, Ryan; Wiley, Christopher D; Wong, Hoi-Shan; Gibbs, Eddy; Iyer, Shankar S; Basisty, Nathan; Wu, Qiuxia; Kim, Ik-Jung; Silva, Elena; Vitangcol, Kaitlyn; Shin, Kyong-Oh; Lee, Yong-Moon; Riley, Rebeccah; Ben-Sahra, Issam; Ott, Melanie; Schilling, Birgit; Scheibye-Knudsen, Morten; Ishihara, Katsuhiko; Quake, Stephen R; Newman, John; Brenner, Charles; Campisi, Judith; Verdin, Eric.
Affiliation
  • Covarrubias AJ; Buck Institute for Research on Aging, Novato, CA, USA.
  • Kale A; UCSF Department of Medicine, San Francisco, CA, USA.
  • Perrone R; Buck Institute for Research on Aging, Novato, CA, USA.
  • Lopez-Dominguez JA; Buck Institute for Research on Aging, Novato, CA, USA.
  • Pisco AO; Buck Institute for Research on Aging, Novato, CA, USA.
  • Kasler HG; Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Schmidt MS; Buck Institute for Research on Aging, Novato, CA, USA.
  • Heckenbach I; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • Kwok R; Buck Institute for Research on Aging, Novato, CA, USA.
  • Wiley CD; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Wong HS; Buck Institute for Research on Aging, Novato, CA, USA.
  • Gibbs E; Buck Institute for Research on Aging, Novato, CA, USA.
  • Iyer SS; Buck Institute for Research on Aging, Novato, CA, USA.
  • Basisty N; Buck Institute for Research on Aging, Novato, CA, USA.
  • Wu Q; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kim IJ; Buck Institute for Research on Aging, Novato, CA, USA.
  • Silva E; Buck Institute for Research on Aging, Novato, CA, USA.
  • Vitangcol K; Buck Institute for Research on Aging, Novato, CA, USA.
  • Shin KO; Buck Institute for Research on Aging, Novato, CA, USA.
  • Lee YM; Buck Institute for Research on Aging, Novato, CA, USA.
  • Riley R; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
  • Ben-Sahra I; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea.
  • Ott M; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
  • Schilling B; Buck Institute for Research on Aging, Novato, CA, USA.
  • Scheibye-Knudsen M; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
  • Ishihara K; Gladstone Institutes, Virology and Immunology, San Francisco, CA, USA.
  • Quake SR; Buck Institute for Research on Aging, Novato, CA, USA.
  • Newman J; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Brenner C; Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Japan.
  • Campisi J; Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Verdin E; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Nat Metab ; 2(11): 1265-1283, 2020 11.
Article in En | MEDLINE | ID: mdl-33199924
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Membrane Glycoproteins / Cellular Senescence / ADP-ribosyl Cyclase 1 / Macrophage Activation / NAD Limits: Animals / Female / Humans / Male Language: En Journal: Nat Metab Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Membrane Glycoproteins / Cellular Senescence / ADP-ribosyl Cyclase 1 / Macrophage Activation / NAD Limits: Animals / Female / Humans / Male Language: En Journal: Nat Metab Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Alemania