Silent New Brain MRI Lesions in Children with MOG-Antibody Associated Disease.
Ann Neurol
; 89(2): 408-413, 2021 02.
Article
in En
| MEDLINE
| ID: mdl-33210746
ABSTRACT
Anti-myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) antibodies are associated clinically with either a monophasic or relapsing disease course. We investigated the frequency and clinical importance of acquired asymptomatic brain magnetic resonance imaging (MRI) lesions in a prospective incident cohort of 74 MOG-IgG positive children with serial MRI scans over a median of 5 years from presentation. Silent new lesions were detected in 14% of MOG-IgG positive participants, most commonly within the first months post-onset, with a positive predictive value for clinically relapsing disease of only 20%. Detection of asymptomatic lesions alone need not prompt initiation of chronic immunotherapy. ANN NEUROL 2021;89408-413.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoantibodies
/
Brain
/
Demyelinating Autoimmune Diseases, CNS
/
Encephalomyelitis, Acute Disseminated
/
Asymptomatic Diseases
/
Myelin-Oligodendrocyte Glycoprotein
/
Multiple Sclerosis
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Ann Neurol
Year:
2021
Document type:
Article
Affiliation country:
Panamá