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Regional Distribution of Fluorine-18-Flubrobenguane and Carbon-11-Hydroxyephedrine for Cardiac PET Imaging of Sympathetic Innervation.
Zelt, Jason G E; Britt, Deron; Mair, Braeden A; Rotstein, Benjamin H; Quigley, Sarah; Walter, Olga; Garrard, Linda; Robinson, Simon; Mielniczuk, Lisa M; deKemp, Robert A; Beanlands, Rob S.
Affiliation
  • Zelt JGE; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Otta
  • Britt D; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada.
  • Mair BA; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
  • Rotstein BH; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Quigley S; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada.
  • Walter O; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada.
  • Garrard L; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada.
  • Robinson S; Lantheus Medical Imaging, North Billerica, Massachusetts, USA.
  • Mielniczuk LM; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Otta
  • deKemp RA; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Otta
  • Beanlands RS; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Molecular Function and Imaging Program, The National Cardiac PET Centre, University of Otta
JACC Cardiovasc Imaging ; 14(7): 1425-1436, 2021 07.
Article in En | MEDLINE | ID: mdl-33221229
OBJECTIVES: The aim of this study was to investigate the regional distribution of novel 18F-labeled positron emission tomographic (PET) tracer flubrobenguane (FBBG) (whose longer half-life could enable more widespread use) to assess myocardial presynaptic sympathetic nerve function in humans in comparison to [11C]meta-hydroxyephedrine (HED). BACKGROUND: The sympathetic nervous system (SNS) is vitally linked to cardiovascular regulation and disease. SNS imaging has shown prognostic value. HED is the most commonly used PET tracer for evaluation of sympathetic function in humans, but widespread clinical use is limited because of the short half-life of 11C. METHODS: A total of 25 participants (n = 6 healthy; n = 14 ischemic cardiomyopathy, left ventricular [LV] ejection fraction [EF] = 34 ± 5%; and n = 5 nonischemic cardiomyopathy, EF = 33 ± 3%) underwent 2 separate PET imaging visits 8.7 ± 7.6 days apart. On 1 visit, participants underwent dynamic HED PET imaging. On a different visit, participants underwent dynamic FBBG PET imaging. The order of testing was random. HED and FBBG global innervation (retention index [RI] and distribution volume [DV]) and regional denervation (% nonuniformity) were quantified to assess regional presynaptic sympathetic innervations. RESULTS: FBBG RI (r2 = 0.72; ICC = 0.79; p < 0.0001), DV (r2 = 0.62; ICC = 0.78; p < 0.0001), and regional denervation (r2 = 0.97; ICC = 0.98; p < 0.0001) correlated highly with HED. Average LV RI values were highly similar between HED (7.3 ± 2.4%/min) and FBBG (7.0 ± 1.7%/min; p = 0.33). Post-hoc analysis did not reveal any between-tracer differences on a regional level (17-segment), suggesting equivalent regional distributions in both patients with and without ischemic cardiomyopathy. CONCLUSIONS: FBBG and HED yield equivalent global and regional distributions in both patients with and without ischemic cardiomyopathy. 18F-labeled PET tracers, such as FBBG, are critical for widespread distribution necessary for multicenter clinical trials and to maximize patient impact.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Positron-Emission Tomography Type of study: Clinical_trials Limits: Humans Language: En Journal: JACC Cardiovasc Imaging Journal subject: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Year: 2021 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Positron-Emission Tomography Type of study: Clinical_trials Limits: Humans Language: En Journal: JACC Cardiovasc Imaging Journal subject: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Year: 2021 Document type: Article Country of publication: Estados Unidos