Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease.

Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund; Saffioti, Francesca; Manon-Jensen, Tina; Leeming, Diana Julie; Moum, Bjørn; Boberg, Kirsten Muri; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, Morten Asser; Thorburn, Douglas

Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund; Saffioti, Francesca; Manon-Jensen, Tina; Leeming, Diana Julie; Moum, Bjørn; Boberg, Kirsten Muri; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, Morten Asser; Thorburn, Douglas.

Affiliation

Vesterhus M; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Nielsen MJ; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.
Hov JR; Department of Clinical Science, University of Bergen, Bergen, Norway.
Saffioti F; Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark.
Manon-Jensen T; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Leeming DJ; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Moum B; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
Boberg KM; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Pinzani M; UCL Institute for Liver and Digestive Health, Division of Medicine, University College London & Royal Free Hospital, London, UK.
Karlsen TH; Department of Clinical and Experimental Medicine, Division of Clinical and Molecular Hepatology, University of Messina, Messina, Italy.
Karsdal MA; Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark.
Thorburn D; Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark.

JHEP Rep ; 3(1): 100178, 2021 Feb.

Article in En | MEDLINE | ID: mdl-33225252

Key words

AIH, autoimmune hepatitis; ALP, alkaline phosphatase; ALT, alanine aminotransferase; APRI, AST to platelet ratio index; AST, aspartate aminotransferase; AUROC, area under the receiver operator characteristics curve; BGM, marker of biglycan degradation; Biomarker; C3M, marker of type III collagen degradation; C4M, marker of type IV collagen degradation; CI, confidence interval; ECM, extracellular matrix; ELF, enhanced liver fibrosis; Fibrosis; GGT, gamma glutamyltransferase; HYA, hyaluronic acid; IBD, inflammatory bowel disease; INR, international normalised ratio; LSM, liver stiffness measurement; PBC, primary biliary cholangitis; PIIINP, N-terminal procollagen type III; PRO-C3; PRO-C3, marker of type III collagen formation; PRO-C5, marker of type V collagen formation; PSC, primary sclerosing cholangitis; Primary biliary cholangitis; Primary sclerosing cholangitis; TE, transient elastography; TIMP-1, tissue inhibitor of metalloproteinase; UC, ulcerative colitis; VICM, marker of citrullinated vimentin degradation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: JHEP Rep Year: 2021 Document type: Article Affiliation country: Noruega Country of publication: Países Bajos

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