Single-center experience on actual mid-term (≥5 years) and long-term (≥10 years) survival outcome in patients with hepatocellular carcinoma after curative hepatectomy: A bimodal distribution.
Medicine (Baltimore)
; 99(48): e23358, 2020 Nov 25.
Article
in En
| MEDLINE
| ID: mdl-33235106
ABSTRACT
Analysis for actual mid-term (≥5 years) and long-term (≥10 years) survivors with hepatocellular carcinoma (HCC) following curative hepatectomy are rarely reported in the literature.This retrospective study aims to study the mid- and long-term survival outcome and associated prognostic factors following curative hepatectomy for HCC in a tertiary referral center.The clinical data of 325 patients who underwent curative hepatectomy for HCC were reviewed. They were stratified into 3 groups for comparison (Group 1, overall survival <5 years; Group 2, overall survival ≥5, and <10 years; Group 3, overall survival ≥10 years). Favorable independent prognostic factors for mid- and long-term survival were analyzed.A bimodal distribution of actual survival outcome was observed, with short-term (<5 years) survival of 52.7% (nâ=â171), mid-term survival of 18.1% (nâ=â59), and long-term survival of 29.2% (nâ=â95). Absence of microvascular invasion (OR 3.690, 95% CI 1.562-8.695) was independent good prognostic factor for mid-term survival. Regarding long-term overall survival, young age (OR 1.050, 95% CI 0.920-0.986), ASA grade ≤2 (OR 3.746, 95% CI 1.325-10.587), high albumin level (OR 1.008, 95% CI 0.920-0.986), solitary tumor (OR 3.289, 95% CI 1.149-7.625) and absence of microvascular invasion (OR 4.926, 95% CI 2.192-11.111) were independent good prognostic factors.Curative hepatectomy results in bimodal actual survival outcome with favorable long-term survival rate of 29.2%. Favorable independent prognostic factors (age, ASA grade, albumin level, tumor number, and microvascular invasion) are identified for overall survival.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Hepatectomy
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Liver Neoplasms
Type of study:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Medicine (Baltimore)
Year:
2020
Document type:
Article