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Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration.
Afshinnekoo, Ebrahim; Scott, Ryan T; MacKay, Matthew J; Pariset, Eloise; Cekanaviciute, Egle; Barker, Richard; Gilroy, Simon; Hassane, Duane; Smith, Scott M; Zwart, Sara R; Nelman-Gonzalez, Mayra; Crucian, Brian E; Ponomarev, Sergey A; Orlov, Oleg I; Shiba, Dai; Muratani, Masafumi; Yamamoto, Masayuki; Richards, Stephanie E; Vaishampayan, Parag A; Meydan, Cem; Foox, Jonathan; Myrrhe, Jacqueline; Istasse, Eric; Singh, Nitin; Venkateswaran, Kasthuri; Keune, Jessica A; Ray, Hami E; Basner, Mathias; Miller, Jack; Vitaterna, Martha Hotz; Taylor, Deanne M; Wallace, Douglas; Rubins, Kathleen; Bailey, Susan M; Grabham, Peter; Costes, Sylvain V; Mason, Christopher E; Beheshti, Afshin.
Affiliation
  • Afshinnekoo E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell
  • Scott RT; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • MacKay MJ; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell
  • Pariset E; Universities Space Research Association (USRA), Mountain View, CA 94043, USA; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Cekanaviciute E; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Barker R; Department of Botany, University of Wisconsin, Madison, WI 53706, USA.
  • Gilroy S; Department of Botany, University of Wisconsin, Madison, WI 53706, USA.
  • Hassane D; Tempus Labs, Inc., Chicago, IL 60654, USA.
  • Smith SM; Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX 77058, USA.
  • Zwart SR; Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Nelman-Gonzalez M; KBR, Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX 77058, USA.
  • Crucian BE; Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX 77058, USA.
  • Ponomarev SA; Institute for the Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia.
  • Orlov OI; Institute for the Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia.
  • Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.
  • Muratani M; Transborder Medical Research Center, and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
  • Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.
  • Richards SE; Bionetics, NASA Kennedy Space Center, Kennedy Space Center, Merritt Island, FL 32899, USA.
  • Vaishampayan PA; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Meydan C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell
  • Foox J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell
  • Myrrhe J; European Space Agency, Research and Payloads Group, Data Exploitation and Utilisation Strategy Office, 2200 AG Noordwijk, the Netherlands.
  • Istasse E; European Space Agency, Research and Payloads Group, Data Exploitation and Utilisation Strategy Office, 2200 AG Noordwijk, the Netherlands.
  • Singh N; Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.
  • Venkateswaran K; Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.
  • Keune JA; Space Medicine Operations Division, NASA Johnson Space Center, Houston, TX 77058, USA.
  • Ray HE; ASRC Federal Space and Defense, Inc., Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Basner M; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Miller J; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA; Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  • Vitaterna MH; Center for Sleep and Circadian Biology, Northwestern University, Evanston, IL 60208, USA; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
  • Taylor DM; Department of Biomedical Informatics, The Children's Hospital of Philadelphia, PA 19104, USA; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Phi
  • Wallace D; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Rubins K; Astronaut Office, NASA Johnson Space Center, Houston, TX 77058, USA.
  • Bailey SM; Department of Environmental & Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: susan.bailey@colostate.edu.
  • Grabham P; Center for Radiological Research, Department of Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA. Electronic address: pwg2@cumc.columbia.edu.
  • Costes SV; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA. Electronic address: sylvain.v.costes@nasa.gov.
  • Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell
  • Beheshti A; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: afshin.beheshti@nasa.gov.
Cell ; 183(5): 1162-1184, 2020 11 25.
Article in En | MEDLINE | ID: mdl-33242416
ABSTRACT
Research on astronaut health and model organisms have revealed six features of spaceflight biology that guide our current understanding of fundamental molecular changes that occur during space travel. The features include oxidative stress, DNA damage, mitochondrial dysregulation, epigenetic changes (including gene regulation), telomere length alterations, and microbiome shifts. Here we review the known hazards of human spaceflight, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration. We also discuss the essential issues related to the health and safety of astronauts involved in future missions, especially planned long-duration and Martian missions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Space Flight / Extraterrestrial Environment Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Cell Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Space Flight / Extraterrestrial Environment Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Cell Year: 2020 Document type: Article