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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
da Silveira, Willian A; Fazelinia, Hossein; Rosenthal, Sara Brin; Laiakis, Evagelia C; Kim, Man S; Meydan, Cem; Kidane, Yared; Rathi, Komal S; Smith, Scott M; Stear, Benjamin; Ying, Yue; Zhang, Yuanchao; Foox, Jonathan; Zanello, Susana; Crucian, Brian; Wang, Dong; Nugent, Adrienne; Costa, Helio A; Zwart, Sara R; Schrepfer, Sonja; Elworth, R A Leo; Sapoval, Nicolae; Treangen, Todd; MacKay, Matthew; Gokhale, Nandan S; Horner, Stacy M; Singh, Larry N; Wallace, Douglas C; Willey, Jeffrey S; Schisler, Jonathan C; Meller, Robert; McDonald, J Tyson; Fisch, Kathleen M; Hardiman, Gary; Taylor, Deanne; Mason, Christopher E; Costes, Sylvain V; Beheshti, Afshin.
Affiliation
  • da Silveira WA; Queens University Belfast, Belfast BT9 5DL, UK.
  • Fazelinia H; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Rosenthal SB; University of California San Diego, La Jolla, CA 92093, USA.
  • Laiakis EC; Georgetown University Medical Center, Washington D.C. 20057, USA.
  • Kim MS; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Meydan C; Weill Cornell Medical College, New York, NY 10065, USA.
  • Kidane Y; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA.
  • Rathi KS; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Smith SM; NASA Johnson Space Center, Houston, TX 77058, USA.
  • Stear B; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Ying Y; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Zhang Y; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Foox J; Weill Cornell Medical College, New York, NY 10065, USA.
  • Zanello S; imec USA, Kissimmee, FL 34744, USA.
  • Crucian B; NASA Johnson Space Center, Houston, TX 77058, USA.
  • Wang D; University of California San Francisco, San Francisco, CA 94115, USA.
  • Nugent A; Hampton University, Hampton, VA 23669, USA.
  • Costa HA; Stanford University, Stanford, CA 94305, USA.
  • Zwart SR; University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Schrepfer S; University of California San Francisco, San Francisco, CA 94115, USA.
  • Elworth RAL; Rice University, Houston, TX 77005, USA.
  • Sapoval N; Rice University, Houston, TX 77005, USA.
  • Treangen T; Rice University, Houston, TX 77005, USA.
  • MacKay M; Weill Cornell Medical College, New York, NY 10065, USA.
  • Gokhale NS; Duke University Medical Center, Durham, NC 27710, USA.
  • Horner SM; Duke University Medical Center, Durham, NC 27710, USA.
  • Singh LN; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Willey JS; Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
  • Schisler JC; The University of North Carolina at Chapel Hill, NC 27599, USA.
  • Meller R; Morehouse School of Medicine, Atlanta, GA 30310, USA.
  • McDonald JT; Georgetown University Medical Center, Washington D.C. 20057, USA.
  • Fisch KM; University of California San Diego, La Jolla, CA 92093, USA.
  • Hardiman G; Queens University Belfast, Belfast BT9 5DL, UK; Medical University of South Carolina, Charleston, SC 29425, USA.
  • Taylor D; The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Mason CE; Weill Cornell Medical College, New York, NY 10065, USA.
  • Costes SV; NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Beheshti A; KBR, NASA Ames Research Center, Moffett Field, CA 94035, USA. Electronic address: afshin.beheshti@nasa.gov.
Cell ; 183(5): 1185-1201.e20, 2020 11 25.
Article in En | MEDLINE | ID: mdl-33242417

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Space Flight / Stress, Physiological / Genomics / Mitochondria Limits: Animals / Humans Language: En Journal: Cell Year: 2020 Document type: Article Affiliation country: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Space Flight / Stress, Physiological / Genomics / Mitochondria Limits: Animals / Humans Language: En Journal: Cell Year: 2020 Document type: Article Affiliation country: Reino Unido