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Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo.
Upadhyay, Udita; Zhuang, Gerald Z; Diatchenko, Luda; Parisien, Marc; Kang, Yuan; Sarantopoulos, Konstantinos D; Martin, Eden R; Smith, Shad B; Maixner, William; Levitt, Roy C.
Affiliation
  • Upadhyay U; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Zhuang GZ; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Diatchenko L; Department of Anesthesiology, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
  • Parisien M; Department of Anesthesiology, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
  • Kang Y; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Sarantopoulos KD; Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Martin ER; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Smith SB; John T. MacDonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Maixner W; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Levitt RC; Department of Anesthesiology, Center for Translational Pain Medicine, Duke University School of Medicine, Durham, NC, USA.
Mamm Genome ; 31(9-12): 287-294, 2020 12.
Article in En | MEDLINE | ID: mdl-33247772
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Biomarkers, Tumor / Calcium / DNA, Complementary / Analgesia / Mutation Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Mamm Genome Journal subject: GENETICA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Biomarkers, Tumor / Calcium / DNA, Complementary / Analgesia / Mutation Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Mamm Genome Journal subject: GENETICA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos