[The levels and clinical significance of serum leptin and transforming growth factor beta1 in silicosis patients].

ABSTRACT

Objective: To investigate the levels and clinical significance of serum leptin and transforming growth beta 1 (TGF-ß1) in silicosis patients. Methods: A total of 52 patients with silicosis (already identified as occupational diseases) were enrolled in the Department of Respiratory and Critical Disease Medicine, the First Hospital of Shanxi Medical University from June 2018 to July 2019. These patients were regarded as silicosis group. They were divided into 25 patients with first stage silicosis, 22 patients with second stage silicosis and 5 patients with third stage silicosis. At the same time, 30 patients with no history of dust exposure in the same period of physical examination were selected as control group. Serum leptin and TGF-ß1 levels were measured by enzyme-linked immunosorbent assay in all investigators. At the same time, the comparison and correlation analysis between groups were carried out, and the diagnostic value was judged by receive operating characteristic (ROC) curve. Results: The serum levels of leptin and TGF-ß1 in silicosis patients were higher than those in the control group, the differences were statistically significant (P<0.05) . The serum levels of leptin in patients with second stage and third stage silicosis were higher than those in the control group and first stage, the differences were statistically significant (P<0.05) . Serum levels of TGF-ß1 in all stage silicosis patients were higher than those in the control group, and third stage silicosis was higher than first stage, the differences were statistically significant (P<0.05) . There was a positive correlation between serum levels of leptin and TGF-ß1 in silicosis group (r(s)=0.400, P<0.05) . The ROC area of leptin and TGF-ß1 combined to predict silicosis was 0.826, with the sensitivity and specificity were 73.10% and 80.00%. Conclusion: The levels of serum leptin and TGF-ß 1 are related to different stages of silicosis, and the combined detection of leptin and TGF-ß 1 can assist the diagnosis of silicosis.