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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes.
Barreca, Marilia; Spanò, Virginia; Montalbano, Alessandra; Cueto, Mercedes; Díaz Marrero, Ana R; Deniz, Irem; Erdogan, Aysegül; Lukic Bilela, Lada; Moulin, Corentin; Taffin-de-Givenchy, Elisabeth; Spriano, Filippo; Perale, Giuseppe; Mehiri, Mohamed; Rotter, Ana; P Thomas, Olivier; Barraja, Paola; Gaudêncio, Susana P; Bertoni, Francesco.
Affiliation
  • Barreca M; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy.
  • Spanò V; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, 6500 Bellinzona, Switzerland.
  • Montalbano A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy.
  • Cueto M; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy.
  • Díaz Marrero AR; Instituto de Productos Naturales y Agrobiología (IPNA-CSIC), La Laguna, 38206 Tenerife, Spain.
  • Deniz I; Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Universidad de La Laguna (ULL), La Laguna, 38200 Tenerife, Spain.
  • Erdogan A; Department of Bioengineering, Faculty of Engineering, Manisa Celal Bayar University, 45119 Manisa, Turkey.
  • Lukic Bilela L; Research Center for Testing and Analysis (EGE MATAL), Ege University Application, 35100 Izmir, Turkey.
  • Moulin C; Department of Biology, Faculty of Science, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.
  • Taffin-de-Givenchy E; Marine Natural Products Team, UMR 7272, Institut de Chimie de Nice, Université Côte d'Azur, CNRS, 06108 Nice, France.
  • Spriano F; Marine Natural Products Team, UMR 7272, Institut de Chimie de Nice, Université Côte d'Azur, CNRS, 06108 Nice, France.
  • Perale G; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, 6500 Bellinzona, Switzerland.
  • Mehiri M; Faculty of Biomedical Sciences, USI, 6900 Lugano, Switzerland.
  • Rotter A; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, Austria.
  • P Thomas O; Marine Natural Products Team, UMR 7272, Institut de Chimie de Nice, Université Côte d'Azur, CNRS, 06108 Nice, France.
  • Barraja P; Marine Biology Station Piran, National Institute of Biology, 1000 Ljubljana, Slovenia.
  • Gaudêncio SP; Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland, Galway (NUI Galway), H91TK33 Galway, Ireland.
  • Bertoni F; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy.
Mar Drugs ; 18(12)2020 Dec 04.
Article in En | MEDLINE | ID: mdl-33291602
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aquatic Organisms / Marine Toxins / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: Italia Country of publication: Suiza

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aquatic Organisms / Marine Toxins / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: Italia Country of publication: Suiza