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The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1.
Mattijssen, Sandy; Kozlov, Guennadi; Gaidamakov, Sergei; Ranjan, Amitabh; Fonseca, Bruno D; Gehring, Kalle; Maraia, Richard J.
Affiliation
  • Mattijssen S; Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
  • Kozlov G; Department of Biochemistry & Centre for Structural Biology, McGill University, Montreal, Canada.
  • Gaidamakov S; Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
  • Ranjan A; Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
  • Fonseca BD; PrimerGen Ltd, Viseu, Portugal.
  • Gehring K; Department of Biochemistry & Centre for Structural Biology, McGill University, Montreal, Canada.
  • Maraia RJ; Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
RNA Biol ; 18(2): 275-289, 2021 02.
Article in En | MEDLINE | ID: mdl-33292040
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Ribonucleoproteins / Autoantigens / RNA, Messenger / Poly(A)-Binding Proteins / Poly(A)-Binding Protein I / Toll-Like Receptor 9 / Toll-Like Receptor 2 / Protein Interaction Domains and Motifs Limits: Humans Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Ribonucleoproteins / Autoantigens / RNA, Messenger / Poly(A)-Binding Proteins / Poly(A)-Binding Protein I / Toll-Like Receptor 9 / Toll-Like Receptor 2 / Protein Interaction Domains and Motifs Limits: Humans Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country: Estados Unidos