3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity.

Lee, Jangho; Song, Ji-Hye; Chung, Min-Yu; Lee, Jin-Hyuk; Nam, Tae-Gyu; Park, Jae Ho; Hwang, Jin-Taek; Choi, Hyo-Kyoung

Lee, Jangho; Song, Ji-Hye; Chung, Min-Yu; Lee, Jin-Hyuk; Nam, Tae-Gyu; Park, Jae Ho; Hwang, Jin-Taek; Choi, Hyo-Kyoung.

Affiliation

Lee J; Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea.
Song JH; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Chung MY; Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea.
Lee JH; Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
Nam TG; Department of Bioinformatics, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea.
Park JH; Major of Food Science and Biotechnology, Division of Bio-convergence, Kyonggi University, Suwon, 16227, Republic of Korea.
Hwang JT; Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea.
Choi HK; Korea Food Research Institute, Jeollabuk-do, 55365, Republic of Korea. jthwang@kfri.re.kr.

Acta Pharmacol Sin ; 42(9): 1449-1460, 2021 Sep.

Article in En | MEDLINE | ID: mdl-33303988

Subject(s)
Key words

3,4-dihydroxytoluene; OPA-induced NAFLD model; epigenetic regulation; non-alcoholic fatty liver disease; ob/ob mice; p300 histone acetyltransferase; rutin metabolites

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechols / Histone Acetyltransferases / Non-alcoholic Fatty Liver Disease / Lipoproteins Limits: Animals / Humans / Male Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Country of publication: Estados Unidos

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