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Photo-Crosslinked Silk Fibroin for 3D Printing.
Mu, Xuan; Sahoo, Jugal Kishore; Cebe, Peggy; Kaplan, David L.
Affiliation
  • Mu X; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
  • Sahoo JK; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
  • Cebe P; Department of Physics and Astronomy, Tufts University, Medford, MA 02155, USA.
  • Kaplan DL; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Polymers (Basel) ; 12(12)2020 Dec 09.
Article in En | MEDLINE | ID: mdl-33316890
ABSTRACT
Silk fibroin in material formats provides robust mechanical properties, and thus is a promising protein for 3D printing inks for a range of applications, including tissue engineering, bioelectronics, and bio-optics. Among the various crosslinking mechanisms, photo-crosslinking is particularly useful for 3D printing with silk fibroin inks due to the rapid kinetics, tunable crosslinking dynamics, light-assisted shape control, and the option to use visible light as a biocompatible processing condition. Multiple photo-crosslinking approaches have been applied to native or chemically modified silk fibroin, including photo-oxidation and free radical methacrylate polymerization. The molecular characteristics of silk fibroin, i.e., conformational polymorphism, provide a unique method for crosslinking and microfabrication via light. The molecular design features of silk fibroin inks and the exploitation of photo-crosslinking mechanisms suggest the exciting potential for meeting many biomedical needs in the future.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Polymers (Basel) Year: 2020 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Polymers (Basel) Year: 2020 Document type: Article Affiliation country: Estados Unidos