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Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.
Buckland, Matthew S; Galloway, James B; Fhogartaigh, Caoimhe Nic; Meredith, Luke; Provine, Nicholas M; Bloor, Stuart; Ogbe, Ane; Zelek, Wioleta M; Smielewska, Anna; Yakovleva, Anna; Mann, Tiffeney; Bergamaschi, Laura; Turner, Lorinda; Mescia, Frederica; Toonen, Erik J M; Hackstein, Carl-Philipp; Akther, Hossain Delowar; Vieira, Vinicius Adriano; Ceron-Gutierrez, Lourdes; Periselneris, Jimstan; Kiani-Alikhan, Sorena; Grigoriadou, Sofia; Vaghela, Devan; Lear, Sara E; Török, M Estée; Hamilton, William L; Stockton, Joanne; Quick, Josh; Nelson, Peter; Hunter, Michael; Coulter, Tanya I; Devlin, Lisa; Bradley, John R; Smith, Kenneth G C; Ouwehand, Willem H; Estcourt, Lise; Harvala, Heli; Roberts, David J; Wilkinson, Ian B; Screaton, Nick; Loman, Nicholas; Doffinger, Rainer; Lyons, Paul A; Morgan, B Paul; Goodfellow, Ian G; Klenerman, Paul; Lehner, Paul J; Matheson, Nicholas J; Thaventhiran, James E D.
Affiliation
  • Buckland MS; Department of Clinical Immunology, Barts Health, London, UK. m.buckland@ucl.ac.uk.
  • Galloway JB; UCL GOSH Institute of Child Health Division of Infection and Immunity, Section of Cellular and Molecular Immunology, London, UK. m.buckland@ucl.ac.uk.
  • Fhogartaigh CN; Centre for Rheumatic Diseases, King's College London, London, UK.
  • Meredith L; Department of Infection, Barts Health NHS Trust, London, UK.
  • Provine NM; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
  • Bloor S; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.
  • Ogbe A; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • Zelek WM; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Smielewska A; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • Yakovleva A; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.
  • Mann T; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • Bergamaschi L; Systems Immunity Institute and Dementia Research Institute, Cardiff University, Cardiff, UK.
  • Turner L; Division of Virology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, UK.
  • Mescia F; PHE - Public Health England Laboratory, Cambridge. Box 236, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.
  • Toonen EJM; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
  • Hackstein CP; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QW, UK.
  • Akther HD; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Vieira VA; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • Ceron-Gutierrez L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Periselneris J; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • Kiani-Alikhan S; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Grigoriadou S; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • Vaghela D; R&D Department, Hycult Biotechnology, Frontstraat 2A, 5405 PB, Uden, The Netherlands.
  • Lear SE; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.
  • Török ME; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • Hamilton WL; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.
  • Stockton J; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • Quick J; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.
  • Nelson P; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
  • Hunter M; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK.
  • Coulter TI; Respiratory Department, King's College Hospital NHS Foundation Trust, UK. Department of Clinical Virology, Addenbrookes, UK.
  • Devlin L; Department of Clinical Immunology, Barts Health, London, UK.
  • Bradley JR; Department of Immunology, Cambridge University Hospitals NHS Trust, Cambridge, UK.
  • Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Ouwehand WH; Cambridge University Hospitals NHS Foundation Trust, Department of Microbiology, Cambridge, UK.
  • Estcourt L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Harvala H; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Roberts DJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Wilkinson IB; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Screaton N; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
  • Loman N; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
  • Doffinger R; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
  • Lyons PA; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
  • Morgan BP; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
  • Goodfellow IG; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
  • Matheson NJ; NIHR BioResource and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
  • Thaventhiran JED; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.
Nat Commun ; 11(1): 6385, 2020 12 14.
Article in En | MEDLINE | ID: mdl-33318491
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Monophosphate / Alanine / Immunity, Humoral / SARS-CoV-2 Limits: Adult / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Monophosphate / Alanine / Immunity, Humoral / SARS-CoV-2 Limits: Adult / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido