Evaluation of rapid antigen detection kit from the WHO Emergency Use List for detecting SARS-CoV-2.
J Clin Virol
; 134: 104712, 2021 01.
Article
in En
| MEDLINE
| ID: mdl-33338894
ABSTRACT
BACKGROUND:
Currently, there are two rapid antigen detection (RAD) kits from the WHO Emergency Use List for detecting SARS-CoV-2.OBJECTIVE:
The Panbio COVID-19 Ag Rapid Test Device was selected to evaluate the performance for detecting SARS-CoV-2. STUDYDESIGN:
Analytical sensitivity for the detection of SARS-CoV-2 virus was determined by limit of detection (LOD) using RT-PCR as a reference method. Clinical sensitivity was evaluated by using respiratory specimens collected from confirmed COVID-19 patients.RESULTS:
The LOD results showed that the RAD kit was 100 fold less sensitive than RT-PCR. Clinical sensitivity of the RAD kit was 68.6 % for detecting specimens from COVID-19 patients.CONCLUSIONS:
The RAD kit evaluated in the present study shared similar performance with another kit from the WHO Emergency Use List, the Standard Q COVID-19 Ag. Understanding the clinical characteristics of RAD kits can guide us to decide different testing strategies in different settings.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reagent Kits, Diagnostic
/
SARS-CoV-2
/
COVID-19
/
Antigens, Viral
Type of study:
Diagnostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
J Clin Virol
Journal subject:
VIROLOGIA
Year:
2021
Document type:
Article