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Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nielsen, Jonas B; Rom, Oren; Surakka, Ida; Graham, Sarah E; Zhou, Wei; Roychowdhury, Tanmoy; Fritsche, Lars G; Gagliano Taliun, Sarah A; Sidore, Carlo; Liu, Yuhao; Gabrielsen, Maiken E; Skogholt, Anne Heidi; Wolford, Brooke; Overton, William; Zhao, Ying; Chen, Jin; Zhang, He; Hornsby, Whitney E; Acheampong, Akua; Grooms, Austen; Schaefer, Amanda; Zajac, Gregory J M; Villacorta, Luis; Zhang, Jifeng; Brumpton, Ben; Løset, Mari; Rai, Vivek; Lundegaard, Pia R; Olesen, Morten S; Taylor, Kent D; Palmer, Nicholette D; Chen, Yii-Der; Choi, Seung H; Lubitz, Steven A; Ellinor, Patrick T; Barnes, Kathleen C; Daya, Michelle; Rafaels, Nicholas; Weiss, Scott T; Lasky-Su, Jessica; Tracy, Russell P; Vasan, Ramachandran S; Cupples, L Adrienne; Mathias, Rasika A; Yanek, Lisa R; Becker, Lewis C; Peyser, Patricia A; Bielak, Lawrence F; Smith, Jennifer A; Aslibekyan, Stella.
Affiliation
  • Nielsen JB; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA. jonas.bille.nielsen@gmail.com.
  • Rom O; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. jonas.bille.nielsen@gmail.com.
  • Surakka I; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Graham SE; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Zhou W; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Roychowdhury T; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Fritsche LG; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Gagliano Taliun SA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Sidore C; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Liu Y; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Gabrielsen ME; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Skogholt AH; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
  • Wolford B; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Overton W; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Zhao Y; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Chen J; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
  • Zhang H; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Hornsby WE; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
  • Acheampong A; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
  • Grooms A; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Schaefer A; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Zajac GJM; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Villacorta L; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Zhang J; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Brumpton B; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Løset M; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Rai V; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Lundegaard PR; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Olesen MS; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Taylor KD; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Palmer ND; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Chen YD; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Choi SH; Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Lubitz SA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
  • Ellinor PT; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
  • Barnes KC; Department of Dermatology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Daya M; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Rafaels N; Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
  • Weiss ST; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lasky-Su J; Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
  • Tracy RP; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Vasan RS; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA, USA.
  • Cupples LA; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Mathias RA; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA, USA.
  • Yanek LR; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Becker LC; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Peyser PA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Bielak LF; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Smith JA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Aslibekyan S; Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Nat Commun ; 11(1): 6417, 2020 12 18.
Article in En | MEDLINE | ID: mdl-33339817
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Genome, Human / Molecular Targeted Therapy / Loss of Function Mutation Type of study: Prognostic_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Genome, Human / Molecular Targeted Therapy / Loss of Function Mutation Type of study: Prognostic_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido