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The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study.
Woo, K S; Chook, P; Hu, Y J; Lao, X Q; Lin, C Q; Lee, Pwa; Kwok, Cyt; Wei, A N; Guo, D S; Yin, Y H; Lau, Kha; Leung, K S; Leung, Y; Celermajer, D S.
Affiliation
  • Woo KS; Institute of Future Cities, The Chinese University of Hong Kong, Hong Kong SAR.
  • Chook P; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR.
  • Hu YJ; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR.
  • Lao XQ; Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR.
  • Lin CQ; Nineth Peoples' Hospital of Chongqing, China.
  • Lee P; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR.
  • Kwok C; Department of Civil and Environment and Engineering, Hong Kong University of Science and Technology, Hong Kong SAR.
  • Wei AN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR.
  • Guo DS; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR.
  • Yin YH; Xuefu Hospital of Chongqing, Second Hospital of Chongqing Medical University, China.
  • Lau K; Department of Medicine, Yu County Provincial Hospital, China.
  • Leung KS; Second Hospital of Chongqing Medical University, China.
  • Leung Y; Department of Civil and Environment and Engineering, Hong Kong University of Science and Technology, Hong Kong SAR.
  • Celermajer DS; Institute of Future Cities, The Chinese University of Hong Kong, Hong Kong SAR.
Int J Epidemiol ; 50(2): 578-588, 2021 05 17.
Article in En | MEDLINE | ID: mdl-33349857
ABSTRACT

BACKGROUND:

Air pollution has been associated with an increase in cardiovascular diseases incidence. To evaluate whether air pollution can accelerate atherogenic processes, we assessed the effects of air pollution on important surrogate markers of atherosclerosis [brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT)].

METHODS:

A total of 1656 Han Chinese (mean age 46.0 + 11.2 years; male 47%) in Hong Kong, Macau, Pun Yu, Yu County and the 3-Gorges Territories (Yangtze River) were studied between 1996 and 2007 [Chinese Atherosclerosis in the Aged and Young Project (the CATHAY Study)]. Cardiovascular risk profiles were evaluated. Particulate matter with an aerodynamic diameter <2.5 µm (PM2.5) parameters were computed from satellite sensors. Brachial FMD and carotid IMT were measured by ultrasound.

RESULTS:

Health parameters [age, gender, body mass index, waist hip ratio (WHR) and glucose)] were similar in lowest and highest PM2.5 exposure tertiles, systolic and diastolic blood pressures and triglycerides were higher (P < 0.001) and low-density cholesterol (LDL-C) was lower in the top PM2.5 tertile (P < 0.001). Brachial FMD [7.84 ± 1.77, 95% confidence interval (CI) 7.59-8.10%, vs 8.50 ± 2.52, 95% CI 8.23-8.77%, P < 0.0001) was significantly lower and carotid IMT (0.68 ± 0.13 mm, 95% CI 0.67-0.69 mm vs 0.63 mm ± 0.15 mm 95% CI 0.62-0.64 mm; P < 0.0001) was significantly thicker in the top PM2.5 tertile compared with the lowest tertile. On multiple regression, FMD was inversely related to PM2.5 (beta = 0.134, P = 0.015) independent of gender, age and blood pressure (model R2 = 0.156, F-value = 7.6, P < 0.0001). Carotid IMT was significantly correlated with PM2.5 exposure (beta = 0.381, P < 0.0001) independent of age, location, gender, WHR, blood pressure and LDL-C (model R2 = 0.408, F-value = 51.4, P-value <0.0001).

CONCLUSIONS:

Air pollution is strongly associated with markers of early atherosclerosis, suggesting a potential target for preventive intervention.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Air Pollution / Atherosclerosis Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Int J Epidemiol Year: 2021 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Air Pollution / Atherosclerosis Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Int J Epidemiol Year: 2021 Document type: Article
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